Using the immune system to help fight disease has been around for many years. Over the past couple of decades, it has been used to fight cancer. Varied oncologic conditions respond well to immunotherapy. While enhancing the immune system is desired to target cancer cells, immunotherapy agents can also cause organ specific toxicities or immune related adverse events because of this desired effect. The recognition of these toxicities and their management is forefront for the clinicians caring for the oncology patient. The new Duke Cancer Institute Center for Immunotherapy is presenting its inaugural symposium to address this topic of toxicities. With a multidisciplinary team of toxicity experts and researchers, how immunotherapy’s side effects impact organ systems will be examined including their diagnosis and management. Emphasis will also be placed on communication between the patient and the interdisciplinary team.