2nd Annual Duke O'Brien Center for Kidney Research Symposium

Durham, NC US
June 19, 2014

Welcome to the 2nd Annual Duke O’Brien Center for Kidney Research (DOCK) Symposium.The DOCK was established in 2012 through support from a P30 grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and by the Duke University School of Medicine and Department of Medicine.This symposium was developed for physicians and trainees who care for patients with kidney and heart disease. We designed the conference to highlight the problem of cardiovascular risk in patients with kidney disease and the multiplying effects on morbidity and mortality of kidney complications in patients with heart disease.In the course of this symposium, current concepts of understanding the interactions between the kidney and cardiovascularsystem will be presented, along with potential strategies for managing affected patients and mitigating risk. This CME activitywill benefit DUHS staff participating in the care of patients with renal and cardiovascular disorders

To view the program agenda please clck the following link: http://dukekidneycenter.org/education/dock-symposium  



Profile Set Up Instructions

Before you register/enroll for any course on the Duke CE Portal you must set up a profile with a valid ID/Password 

If you do NOT have a profile for the Duke CE Portal, please follow the steps below:

  1. Access the Duke CE Portal to create your profile and establish an ID/password. This link will open in a separate browser window.  Note that fields marked with an asterisk (*) are required. For further instructions and reference use the quick reference card The Duke CE Portal will send a confirmation notice to your email address. Open this email message and click on the link in the email to confirm your profile set up.
  2. The confirmation link will take you back to the Duke CE Portal where you will enter and confirm the password that you set up.  
  3. Once you enter the password, scroll to the top of the page to see the "GREEN BANNER" that reads "The changes have been saved"
  4. Keep a record of your ID/password. You will need to complete the certification process and login to the the Duke CE Portal at any time.


How to Register/Enroll Into a Course in ETHOS

  • In the upper right hand corner of the Ethos Home Page, type in the name of the course, 2nd Annual Duke O'Brien Center for Kidney Research Symposium, in the search bar.
  • Click on the web link which will then direct you to the course landing page.
  • Click on Take Course at the bottom of the page to complete the registration process.
  • Upon completion of registration, a confirmation email will be sent providing the course details.

Learning Objectives

  1. Understand expression of the EGFR in the kidney and its roles in regeneration after acute kidney injury.
  2. Understand the role of the EGFR in mediating glomerular injury in diabetic nephropathy.
  3. Understand the role of the EGFR in mediating tubulointerstitial injury in response to angiotensin II.
  4. Understand the biochemistry of Cullin-3.
  5. Understand how Cullin-3 regulates Rho Kinase activity.
  6. Understand how Cullin-3 regulates responsiveness of sooth muscle to nitric oxide.
  7. Understand the concept of biased signaling at GPCRs.
  8. Understand how this new idea can be leveraged to develop a new class of therapeutic agent


Course summary
Available credit: 
  • 5.50 AMA PRA Category 1 Credit(s)
Registration Opens: 
Registration Expires: 
Activity Starts: 
06/19/2014 - 7:30am
Activity Ends: 
06/19/2014 - 5:00pm
Trent Seman's Center, Great Hall
8 Searle Center Drive
Durham, NC 27710
United States

Disclosures TBA:


2nd Annual Duke O’Brien Center for Kidney Research Symposium

June 19, 2014

Speakers’ Contact Information


Raymond C. Harris, MD

Ann and Roscoe Robinson Professor of Medicine

Chief, Division of Nephrology and Hypertension, C-3121 MCN

Vanderbilt University School of Medicine

Nashville, TN  37232



Matthew Hirschey, PhD

Assistant Professor of Medicine

Box 3937

Duke University Medical Center

Durham, NC  27710



Mary E. Klotman, MD

R.J. Reynolds Professor

School of Medicine

Chair, Department of Medicine

Duke University Medical Center

Durham, NC  27710



Robert J. Lefkowitz, MD

James B. Duke Professor of Medicine

Investigator, Howard Hughes Medical Institute

Duke University Medical Center

PO Box 3821

Durham, NC 27710



Svati Shah, MD

Associate Professor of Medicine

Box 3445

Duke University Medical Center

Durham, NC  27710



Curt D. Sigmund, PhD

Roy J. Carver Chair in Hypertension Research

Chair and Department Executive Officer, Department of Pharmacology

Roy J. and Lucille A. Carver College of Medicine University of Iowa

Iowa City, IA  52242



Crystal Tyson, MD

Medical Instructor

Department of Medicine

Box 3487

Duke University Medical Center

Durham, NC  27710


Available Credit

  • 5.50 AMA PRA Category 1 Credit(s)
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