4th Annual Duke O'Brien Center for Kidney Research Symposium

Durham, NC US
June 23, 2016

The goal of our program is to unravel the mechanisms underlying the profound impact kidney disease imparts on cardiovascular morbidity and mortality. The goal of the DOCK center is to explore how kidney disease interacts with the cardiovascular system using a genetic and basic science approach. We will also foster clinical and translational research aimed at the inter-relationships between CKD, hypertension, and cardiovascular disease.  Our annual symposium is an opportunity to convey to the basic science and clinical community at Duke and in the region the advances made toward our goals.  

Learning Objectives

At the conclusion of this activity, participants should be able to:

  • Explain the differences between pragmatic and explanatory clinical trials.
  • Identify the advantages and challenges of embedding clinical research into clinical care delivery.
  • Interpret the extent to which results of the SPRINT can and should be applied to various patient populations, including patients with kidney and cardiovascular disease.
  • Review additional analysis in progress that will increase learning from SPRINT.
  • Recognize the major causative role for genetic abnormalities in chronic kidney disease.
  • Assess the potential for genetic analysis to identify novel therapeutic targets.
  • Assess the utility of using the zebrafish as an in vivo model of sickle cell disease nephropathy.
  • Describe the possible kidney cell types that may be involved in APOL1 - induced nephropathy.
  • Identify approaches to identify disease risk alleles in pedigrees.
  • Recognize the role of the IL-15 receptor in renal posocyte biology and disease.
  • Define the role of the endothelin system in regulating blood pressure
  • Describe the basis of biased agonism as a novel treatment approach.
Course summary
Available credit: 
  • 4.00 JA Credit - AH
Registration Opens: 
06/23/2016
Registration Expires: 
10/20/2016
Activity Starts: 
06/23/2016 - 9:00am EDT
Activity Ends: 
06/23/2016 - 3:00pm EDT
Add to calendar: 
Trent Semans Center - Great Hall
Duke University Medical Center
Durham, NC 27710
United States
  • Mary Foster, MD
  • Laura Svetkey, MD
  • Steven Crowley, MD
  • Robert Spurney, MD
  • Susan Gurley, MD, PhD
  • Elizabeth Hauser, PhD
  • Eric Peterson, MD
  • Howard Rockman, MD
  • Nicholas Katsanis, PhD
  • Allison Ashely-Koch, PhD
  • William C. Cushman, MD
  • Laura Dember, MD
  • Gentzon Hall, MD, PhD
  • Sudarhan Rajagopal, MD

Available Credit

  • 4.00 JA Credit - AH
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