1. Describe the cellular and molecular mechanisms underlying immunothrombosis, including the role of Factor XII, heme, and platelet-immune interactions in disease pathology.

2.Assess how endothelial dysfunction contributes to thrombotic risk, with emphasis on red cell deformability, lipid metabolism, and phosphatidylserine exposure.

3. Explain the mechanisms and clinical implications of cancer-associated thrombosis, including VWF and tissue factor roles in tumor biology and metastasis.

4. Evaluate evolving approaches to clinical management of thrombotic and bleeding disorders, including complications in transgender care, hemoglobinopathies, and thrombophilias.

5. Explore the applications of microfluidic and biomechanical systems in hematologic research and diagnostics,particularly in the context of trauma, transfusion medicine, and sickle cell disease.

6.Integrate knowledge of thromboinflammatory pathways across age groups and disease states to identify potential therapeutic strategies and improve patient care.