Racial and ethnic minorities experience higher rates of disease, disability, and death than their white counterparts. Research to eliminate racial and ethnic disparities in health is a national priority. The Health Disparities Research Curriculum (HDRC) was developed to raise awareness about health disparities research among junior investigators and to teach the skills required to incorporate principles of disparities research into their particular areas of research focus. Although this curriculum focuses primarily on racial and ethnic disparities, the principles, methods, and examples will be broadly applicable to other disparities (e.g., gender). The HDRC is designed to increase knowledge and skill of participants in the evaluation, design, and conduct of health disparities research. The curriculum consists of monthly sessions which combine didactics and student activities addressing: Nomenclature and framework for approaching research involving health disparities Contributors to health disparities Role of implicit bias in disparities research Health disparities research methods across the translational spectrum Conduct of health disparities research focused on the clinical encounter