This course is designed to educate physicians, residents, medical students, nurses and allied health professionals about the physiology and medicine related to human performance in the extremes of environments. From the depths of the sea, to the reaches or outer space; from the sweltering Sahara, to the frigid Antarctica, and peak of Mt. Everest, the human body has limits on its function and ability to adapt to environmental stressors. This course will teach concepts of human (and animal) adaptation to these environments, and discuss facets of engineering and technological advances which will be needed to push the boundaries of human habitation.