As the population ages, the number of people with end stage organ disease and cancer is increasing. Solid organ and stem cell transplantation is emerging as a potential lifesaving intervention for many of these devastating diseases. Historically, solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) have only been offered to younger adults (age less than 65 years). Advances in the surgical and medical care of transplant recipients has made feasible transplantation of older adults, as well as the use of organs and tissues from older donors, but outcomes in older recipient and with use of older donor organs has not been well studied.