Learning Objectives:

1. Review outcomes with conventional care of systemic sclerosis (SSc) with lung involvement

2.  Describe the techniques of autologous hematopoietic cell transplantation (HCT)

3.  Examine the evidence of restoration of a normalized immune repertoire in autoimmune disease following HCT

4.  Compare the design and outcomes of recent randomized trials comparing HCT to cyclophosphamide

5.  Formulate criteria for timely referral for HCT in patients with SSc and pulmonary involvement